Library Compositions and Methods for Acyclic Identification of Aptamers

The present invention provides improved aptamer libraries useful for discovery of aptamers that have high binding affinity for a single or a plurality of targets. The libraries contain higher copies of each member candidate such that they are more likely to be available to the application of acyclic...

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Bibliographische Detailangaben
Hauptverfasser: BORER PHILIP N, MCPIKE MARK P
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides improved aptamer libraries useful for discovery of aptamers that have high binding affinity for a single or a plurality of targets. The libraries contain higher copies of each member candidate such that they are more likely to be available to the application of acyclic identification methods that obviate the most time-consuming and costly step in traditional SELEX method, the multiple cycles of evolutionary selection.