BIOTINYLATED POLYSACCHARIDES HAVING AN ANTITHROMBOTIC ACTIVITY AND IMPROVED METABOLIC STABILITY

BIOTINYLATED POLYSACCHARIDES HAVING AN ANTITHROMBOTIC ACTIVITY AND IMPROVED METABOLIC STABILITY

The invention relates to novel polysaccharides with an antithrombotic activity, having at least one covalent bond with biotin or a biotin derivative, wherein said covalent bond is resistant to metabolic cleavage and comprises a linkage X selected from the group consisting of -O-, -N(R)-, -N(R)-CO- a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DUCHAUSSOY PHILLIPPE, BIANCIOTTO MARC, TROUILLEUX PATRICK, DRIGUEZ PIERRE ALEXANDRE, LASSALLE GILBERT, LE-DREF PIERRICK, THIERY JEANRISTOPHE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The invention relates to novel polysaccharides with an antithrombotic activity, having at least one covalent bond with biotin or a biotin derivative, wherein said covalent bond is resistant to metabolic cleavage and comprises a linkage X selected from the group consisting of -O-, -N(R)-, -N(R)-CO- and -N(R')-CO-N(R'')-, wherein R is an alkyl group and R' and R'', which may be identical or different, are, independently of one another, a hydrogen atom or alkyl group.