NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES

NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES

The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R', R1 and R2, where R' is H or Ac...

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Bibliographische Detailangaben
Hauptverfasser: SUGIYAMA SHIN, TREPANIER DAN J, URE DARREN R, MCGLADE DAVID H, FENSKE BRUCE W, CZAJKOWSKI DAVID P, ABEL MARK D, HEGMANS ALEXANDER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R', R1 and R2, where R' is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl.