GLP-1 RECEPTOR AGONIST COMPOUNDS HAVING STABILIZED REGIONS

GLP-1 RECEPTOR AGONIST COMPOUNDS HAVING STABILIZED REGIONS

The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regi...

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Bibliographische Detailangaben
Hauptverfasser: SOARES CHRISTOPHER J, GHOSH SOUMITRA S, COATS EUGENE, SHARMA ABHINANDINI, ALFARO-LOPEZ JOSUE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4.