Gastroretentive Solid Oral Dosage Forms with Swellable Hydrophilic Polymer

The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a swellable hydrophilic polymer and an active agent, w...

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Bibliographische Detailangaben
Hauptverfasser: DING GUANGBIN, KOU JIM H, CHIN SHOOK-FONG, MASAND NATASHA G, ALANI LAMAN LYNN
Format: Patent
Sprache:eng
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Zusammenfassung:The disclosure provides multiparticulate systems that give release of active agents with a narrow window of absorption such that there is bioavailability to a patient. The disclosure provides a composition comprising microparticulates comprising a swellable hydrophilic polymer and an active agent, wherein the swellable hydrophilic polymer is substantially non-crosslinked intramolecularly, and the size of the microparticulates is about 500 μm or less.