AMINOMETHYL QUINOLONE COMPOUNDS

The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and composit...

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Bibliographische Detailangaben
Hauptverfasser:	QI LIDA, FIROOZNIA FARIBORZ, THAKKAR KSHITIJ C, CHEUNG ADRIAN WAI-HING, QIAN YIMIN, HAYDEN STUART, BILOTTA JOSEPH A, GUERTIN KEVIN RICHARD, MARCOPULOS NICHOLAS, MERTZ ERIC, LUKACS-LESBURG CHRISTINE M, SO SUNG-SAU, HAYNES NANCY-ELLEN, TAN JENNY
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.