COMPOSITIONS AND METHODS FOR DETECTING CARDIOTOXICITY

COMPOSITIONS AND METHODS FOR DETECTING CARDIOTOXICITY

The present disclosure provides methods and compositions for detecting the presence and activity of creatine transporter proteins (CrT) in biological samples comprising screening the samples for CrT using antibodies that bind to the CrT. The methods are useful to detect the onset of cardiotoxicity i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JACOBS DANNY O, SANTACRUZ KOZARINAS LUCIA A, BURCHETTE, JR. JAMES L
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The present disclosure provides methods and compositions for detecting the presence and activity of creatine transporter proteins (CrT) in biological samples comprising screening the samples for CrT using antibodies that bind to the CrT. The methods are useful to detect the onset of cardiotoxicity in subjects undergoing treatment with anthrocyclines or those susceptible to heart-related conditions. The methods and compositions described herein in can be practiced with diagnostic kits.