DESIGN OF MOLECULES

DESIGN OF MOLECULES

A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOPKINS ANDREW LEE, BESNARD JEREMY
Format: Patent
Sprache:eng
Schlagworte:
ANALOGUE COMPUTERS
CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
PHYSICS
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Beschreibung
Zusammenfassung:A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectives (OA1-n), where n is at least one; defining a population (PG=0) of at least one molecule; selecting an initial population (Pparent) of at least one molecule (I1−In) from the population (PG=0); and evaluating members (I1−In) of the initial population (Pparent) against at least one of the n achievement objectives (OA1-x), where x is from 1 to n.