Pyrazolopyrimidines for treating CNS disorders

Pyrazolopyrimidines for treating CNS disorders

Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C-, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydr...

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Hauptverfasser: GUTCAITAS ALEKSANDRS, KAUSS VALERJANS, FOTINS JURIS, HECHENBERGER MIRKO, DEKUNDY ANDRZEJ, HENRICH MARKUS, JATZKE CLAUDIA, WEIL TANJA, DANYSZ WOJCIECH, PARSONS CHRISTOPHER GRAHAM RAPHAEL, NAGEL JENS, KALVINSH IVARS, ZEMRIBO RONALDS
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2, Y3, Y4 represent N or C-, whereby at least two of the groups Y1 to Y4 represent a carbon atom, R1 represents chloro or bromo, R2 to R7 represent e.g. hydrogen, methyl or ethyl; and R10 and R11 independently represent e.g. hydrogen or C1-C6alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.