AMINE-BASED COMPOUND AND USE THEREOF

Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and...

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Hauptverfasser: MATSUI RYO, SUZUKI SHIGERU, KIKUMOTO SHIGEYUKI, YANAKA MIKIRO, YAMAMOTO MASASHI, SAITOU ATSUSHI, ONO MASAHIRO, SAWA TOMOHIRO
Format: Patent
Sprache:eng
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Zusammenfassung:Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH2, C( O), NR11, or CHR35 and D represents a group represented by the following formula (6): [Formula 4] -Q-Y-B  (6) where Q represents a single bond, NR12, or a group represented by the formula (13): and Y represents a group represented by the following formula (7): [Formula 6] -(CR18R19)m3- or -(CR20R21)m4-z-(CR22R23)m5-  (7) where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.