ORGANIC COMPOUNDS

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WARMUTH MARKUS, HALLEK MICHAEL, VOS SVEN DE, OTTMANN OLIVER GERHARD, HOELZER DIETER, KREIL SEBASTIAN, MUELLER MARTIN, HOFMANN WOLF-KARSTEN, HOCHHAUS ANDREAS, DRUKER BRIAN JAY, KOEFFLER PHILLIP, BARTHE CHRISTOPHE, CORBIN AMIE, MAHON FRANCOIS-XAVIER, GSCHAIDMEIER HARALD, CONY-MAKHOUL PASCALE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.