INSULIN-OLIGOMER CONJUGATES, FORMULATIONS AND USES THEREOF

INSULIN-OLIGOMER CONJUGATES, FORMULATIONS AND USES THEREOF

An insulin compound coupled to a modifying moiety having a formula: -X-R1-Y-PAG-Z-R2  (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond, either R1 or R2 is a lower alkyl,...

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Bibliographische Detailangaben
Hauptverfasser: MALKAR NAVDEEP B, JAMES KENNETH D, EKWURIBE NNOCHIRI N, FERRO MICHELLE, PUSKAS MONICA, RADHAKRISHNAN BALASINGAM, AGGARWAL DITI, MILLER MARK A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:An insulin compound coupled to a modifying moiety having a formula: -X-R1-Y-PAG-Z-R2  (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond, either R1 or R2 is a lower alkyl, optionally including a carbonyl group, and when R1 is a lower alkyl, R2 is a capping group, and PAG is a linear or branched carbon chain incorporating one or more alkalene glycol moieties, and optionally incorporating one or more additional moieties selected from the group consisting of -S-, -O-, -N-, and -C(O)-.