TERMINATION DEVICES AND RELATED METHODS

Devices, methods and kits for forming and/or advancing one or more knots in a tether (e.g., during a tissue modification procedure) are described. In some variations, a tether may be used to gather or compress tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may then be locked to maintain the tension (e.g., by forming one or more knots in the tether). In some variations, an open knot may be advanced along a tether before being converted into a closed knot. The devices, methods and/or kits may be used, for example, in minimally invasive procedures.