KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY

The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthe...

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Bibliographische Detailangaben
Hauptverfasser:	NANJAPPAN PALANIAPPA, NUNN ADRIAN D, BUSSAT PHILIPPE, MARINELLI EDMUND R, PILLAI RADHAKRISHNA K, SHRIVASTAVA AJAY, YAN FENG, SWENSON ROLF E, FAN HONG, LINDER KAREN E, POCHON SIBYLLE, ARBOGAST CHRISTOPHE, RAMALINGAM KONDAREDDIAR, VON WRONSKI MATHEW A, SONG BO, KHURANA SUDHA
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD