PROCESS FOR THE PREPARATION OF EFAVIRENZ

PROCESS FOR THE PREPARATION OF EFAVIRENZ

A simple, cost-effective process for preparation of efavirenz of formula (I) comprising reacting a solution of 5-chloro-α-(cyclopropylethynyl)-2-amino-α-trifluoromethyl) benzene methanol of formula (II) in an organic solvent with triphosgene in the presence of an inorganic base at a temperature rang...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MEHTA SATISH RAMANLAL, DESHMUKH ABDULRAKHEEB ABDULSUBHAN, GURJAR MUKUND KESHAV, DESHMUKH SANJAY SHANKAR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A simple, cost-effective process for preparation of efavirenz of formula (I) comprising reacting a solution of 5-chloro-α-(cyclopropylethynyl)-2-amino-α-trifluoromethyl) benzene methanol of formula (II) in an organic solvent with triphosgene in the presence of an inorganic base at a temperature range −5° C. to 25° C., adding water and isolating compound of formula (I).