METHOD OF DETERMINING THE WEIGHT OF THE COATING TO BE APPLIED TO FORM A CONTROLLED RELEASE DOSAGE FORM

METHOD OF DETERMINING THE WEIGHT OF THE COATING TO BE APPLIED TO FORM A CONTROLLED RELEASE DOSAGE FORM

A method of coating spherical particles of a beta blocker compound which is based on (a) determining the surface area of a weighed sample of said spherical particles; (b) determining the weight of coating material per surface area unit of spherical particles that will provide a desired release profi...

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Bibliographische Detailangaben
Hauptverfasser: RUBINO ORAPIN, MUELLER OLIVER, JONES DAVID, PRASCH ARMIN, FEMIA ROBERT A, ETTNER ANNE, POLLINGER NORBERT, RANGUNATHAN NARAYAN
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A method of coating spherical particles of a beta blocker compound which is based on (a) determining the surface area of a weighed sample of said spherical particles; (b) determining the weight of coating material per surface area unit of spherical particles that will provide a desired release profile for said beta-blocker; (c) determining the surface area of a subsequent batch of spherical particles containing the same beta; (d) coating the subsequent batch of spherical particles with the coating applied in step (b) to provide a coating having substantially the same weight of coating material per surface area unit of spherical particles as determined in step (b).