MULTI BLOCK COPOLYMERS

MULTI BLOCK COPOLYMERS

A multi-block copolymer comprises at least one hydrophilic collagen-like block and at least one silk-like block. The silk-like block comprises an amino acid sequence ((GA)mGX)n (SEQ ID NO: 10), wherein G is glycine, A is alanine, m and n are at least 2. X is an ionizable amino acid. The ionizable am...

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Hauptverfasser: WERTEN MARC WILLEM THEODOOR, DE WOLF FREDERIK ANTON, MARTENS AERNOUT ANDERS, EGGINK GERRIT, COHEN STUART MARTINUS ABRAHAM
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:A multi-block copolymer comprises at least one hydrophilic collagen-like block and at least one silk-like block. The silk-like block comprises an amino acid sequence ((GA)mGX)n (SEQ ID NO: 10), wherein G is glycine, A is alanine, m and n are at least 2. X is an ionizable amino acid. The ionizable amino acid can be inducedle to bear a positive charge or a negative charge. The ionizable amino acid bearing the positive charge is preferably histidine and the one bearing the negative charge is preferably glutamic acid.