Markers associated with the therapeutic efficacy of glatiramer acetate

Markers associated with the therapeutic efficacy of glatiramer acetate

The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of autoimmune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsive...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SINGER CLARA, GROSSMAN IRIS, AVIDAN NILI, HAYARDENY LIAT, MILLER ARIEL, BECKMANN JACQUES, BEN-ASHER EDNA, GOLDSTAUB DAN, LANCET DORON
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of autoimmune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPP1 and IL-12RB2.