NETWORK POPULATION MAPPING

Provided herein are methods for mapping quantitative trait loci in a connected population of organisms. The invention includes evaluating associations between markers and a trait of interest using network population mapping (NPM). The methods include assembling a network of individual members for as...

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Bibliographische Detailangaben
Hauptverfasser:	CATON HOMER GENE, WARNER TODD LEE, KADARU SURESH BABU, LI MIN, GUO ZHIGANG, KISHORE VENKATA KRISHNA
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NEW PLANTS OR PROCESSES FOR OBTAINING THEM PHYSICS PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are methods for mapping quantitative trait loci in a connected population of organisms. The invention includes evaluating associations between markers and a trait of interest using network population mapping (NPM). The methods include assembling a network of individual members for association mapping, wherein the members are connected at the allelic level. Members of the network are grouped according to a shared haplotype at one or more marker loci, and the network can be used to identify or validate QTL within the chromosomal region surrounding or flanked by the marker loci. The methods further include a means for estimating and ranking the effects of multiple alleles across the mapping population. Further provided is a novel simple interval mapping model as well as a novel composite interval mapping model for evaluating allele-specific associations across a connected mapping population.