Preparation of Saturated Ketone Morphinan Compounds

The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerizati...

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Bibliographische Detailangaben
Hauptverfasser: BERBERICH DAVID W, JUNG CATHERINE K, JIANG TAO, WANG PETER X, GURUSAMY NARAYANASAMY
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.