High Throughput Screening Assay for the TRPM5 Ion Channel
There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LEE S. PAUL YANG QIFENG BRYANT ROBERT W BUBER M.N. TULU PALMER R. KYLE |
| description | There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2010248988A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2010248988A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2010248988A13</originalsourceid><addsrcrecordid>eNrjZLD0yEzPUAjJKMovTc8oKC1RCE4uSk3Ny8xLV3AsLk6sVEjLL1IoyUhVCAkK8DVV8MzPU3DOSMzLS83hYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBoYGRiYWlhYWjobGxKkCAG5rLmA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>High Throughput Screening Assay for the TRPM5 Ion Channel</title><source>esp@cenet</source><creator>LEE S. PAUL ; YANG QIFENG ; BRYANT ROBERT W ; BUBER M.N. TULU ; PALMER R. KYLE</creator><creatorcontrib>LEE S. PAUL ; YANG QIFENG ; BRYANT ROBERT W ; BUBER M.N. TULU ; PALMER R. KYLE</creatorcontrib><description>There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.</description><language>eng</language><subject>CHEMISTRY ; COMBINATORIAL CHEMISTRY ; DERIVATIVES THEREOF ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PHYSICS ; SUGARS ; TESTING</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100930&DB=EPODOC&CC=US&NR=2010248988A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100930&DB=EPODOC&CC=US&NR=2010248988A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEE S. PAUL</creatorcontrib><creatorcontrib>YANG QIFENG</creatorcontrib><creatorcontrib>BRYANT ROBERT W</creatorcontrib><creatorcontrib>BUBER M.N. TULU</creatorcontrib><creatorcontrib>PALMER R. KYLE</creatorcontrib><title>High Throughput Screening Assay for the TRPM5 Ion Channel</title><description>There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.</description><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PHYSICS</subject><subject>SUGARS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD0yEzPUAjJKMovTc8oKC1RCE4uSk3Ny8xLV3AsLk6sVEjLL1IoyUhVCAkK8DVV8MzPU3DOSMzLS83hYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBoYGRiYWlhYWjobGxKkCAG5rLmA</recordid><startdate>20100930</startdate><enddate>20100930</enddate><creator>LEE S. PAUL</creator><creator>YANG QIFENG</creator><creator>BRYANT ROBERT W</creator><creator>BUBER M.N. TULU</creator><creator>PALMER R. KYLE</creator><scope>EVB</scope></search><sort><creationdate>20100930</creationdate><title>High Throughput Screening Assay for the TRPM5 Ion Channel</title><author>LEE S. PAUL ; YANG QIFENG ; BRYANT ROBERT W ; BUBER M.N. TULU ; PALMER R. KYLE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2010248988A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PHYSICS</topic><topic>SUGARS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LEE S. PAUL</creatorcontrib><creatorcontrib>YANG QIFENG</creatorcontrib><creatorcontrib>BRYANT ROBERT W</creatorcontrib><creatorcontrib>BUBER M.N. TULU</creatorcontrib><creatorcontrib>PALMER R. KYLE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEE S. PAUL</au><au>YANG QIFENG</au><au>BRYANT ROBERT W</au><au>BUBER M.N. TULU</au><au>PALMER R. KYLE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>High Throughput Screening Assay for the TRPM5 Ion Channel</title><date>2010-09-30</date><risdate>2010</risdate><abstract>There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2010248988A1 |
| source | esp@cenet |
| subjects | CHEMISTRY COMBINATORIAL CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS SUGARS TESTING |
| title | High Throughput Screening Assay for the TRPM5 Ion Channel |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T04%3A28%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LEE%20S.%20PAUL&rft.date=2010-09-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2010248988A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |