PIPERIDINE/PIPERAZINE DERIVATIVES

The invention relates to a DGAT inhibitor of formula (I): including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents -C( O)-; -O-C( O)-; C( O)-C( O)-; -NRx-C( O)-; -Z1-C(O)-; -Z1-NRx-C( O)-; -C( O)-Z1-; -NRx-C( O)-Z1-; -S( O)p-; -C( S)-; -NRx-C( S)-; -Z1-C( S)-; -Z1-NRx-C( S)-; -C( S)-Z1-; NRx-C( S)-Z-; Y represents NRx-C(=0)-Z2-; -NRx-C(=0)-Z2-NRy-; -NRx-C(=0)-Z 2-NRy-C(=0)-; -NRx-C(=0)-Z2-NRy-C(=0)-; O-; -NRx-C(=0)-Z2-0-; -NRx-C(=0)-Z2-0-C(=0)-; -NRx-C(=0)-Z2-C(=0)-; -NRx-C(=0)-Z2-C(=0)-; -NRx-C(=0)-0-Z2-C(=0)-; -NRx-C(=0)-0-Z2-C(=0)-0-; -NRx-C( O)-O-Z2-O-C( O)-; -NRx-C( O)-Z2-C( O)-NRy-; -NRx-C( O)-Z2-NRy-C(=0)-NRy-; -C( O)-Z2-; -C( O)-Z2-O-; -C(=0)-NRx-Z2-; -C(=0)-NRx-Z2-0-; -C(=0)-NRx-Z2-C(=0)-0-; -C(=0)-NRx-Z2-0-C(=0)-; -C(=0)-NRx-Z2-NRy-; -C(=0)-NRx-Z2-NRy-C(=0)-; -C(=0)-NRx-Z2-NRy-C(=0)-0-; R1 represents C1-12alkyl optionally substituted with cyano, C1-4alkyloxy, C1-4alkyl-oxyC1-4alkyloxy, C3-6Cycloalkyl or aryl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; adamantanyl; aryl1; aryl1C1-6alkyl; Het1; or Het1C1-6alkyl; provided that when Y represents -NRx-C( O)-Z2-; -NRx-C(=0)-Z2-NRy; -NRx-C( O)-Z2-C( O)-NRy-; -C( O)-Z2-; -NRx-C(=0)-Z2-NRy-C(=0)-NRy-; -C( O)-NR-Z2-; -C( O)-NR-O-Z2-; or -C(=0)-NRx-Z2-NRy-; then R1 may also represent hydrogen; R2 represents hydrogen, C1-12alkyl, C2-6alkenyl or R3; provided that if X represents -O-C( O)-; the R2 O represents R3; and provided that (A) is excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.