Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L′ are suitable leaving groups, with a compound of formula (III) UNH2   (III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by...

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Bibliographische Detailangaben
Hauptverfasser: GUNTRIP STEPHEN BARRY, COCKERILL GEORGE STUART, LACKEY KAREN ELIZABETH, CARTER MALCOM CLIVE, SMITH KATHRYN JANE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) wherein L and L′ are suitable leaving groups, with a compound of formula (III) UNH2   (III) to prepare a compound of formula (IV) and subsequently (b) substituting the group R1 by replacement of the leaving group L′.