Phosphoinositide Modulation For The Treatment Of Neurodegenerative Diseases

The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or "PIP") and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or "PIP2"), the use of such agents fo...

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Bibliographische Detailangaben
Hauptverfasser:	KIM TAE-WAN, MCINTIRE LAURA BETH JOHNSON, DIPAOLO GILBERT, KANG MIN SUK, BERMAN DIEGO EZEQUIEL
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or "PIP") and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or "PIP2"), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with gamma-secretase and lipid rafts.