NOVEL AND PRACTICAL PROCESS FOR EXCLUSIVELY PRODUCING (S)-9-FLUORO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-2,3-DIHYDRO-7H-PYRIDO-[1,2,3,DE][1,4]BENZOXAZINE-6-CARBOXYLIC ACID HEMIHYDRATE

NOVEL AND PRACTICAL PROCESS FOR EXCLUSIVELY PRODUCING (S)-9-FLUORO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-2,3-DIHYDRO-7H-PYRIDO-[1,2,3,DE][1,4]BENZOXAZINE-6-CARBOXYLIC ACID HEMIHYDRATE

A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic sol...

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Bibliographische Detailangaben
Hauptverfasser: SHEN XIAOFENG, ZHU HANGCHANG, JIN CHENMING, YANG PINGAI, WANG ZHEQING, SHU LIJIAN, GUO WEIFENG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.