ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS

The present invention relates to alpha1, and/or alpha1d adrenergic receptor antagonists, which can function as alpha1a and/or alpha1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through alpha1a and/or an adrenergic receptor. Compounds disclosed...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GUPTA PRAFUL, MISHRA ANURAG, SALMAN MOHAMMAD, YADAV GYAN CHAND, KAPKOTI GOBIND SINGH, CHUGH ANITA, SHARMA SOMESH, ANAND NITYA, NANDA KAMNA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to alpha1, and/or alpha1d adrenergic receptor antagonists, which can function as alpha1a and/or alpha1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through alpha1a and/or an adrenergic receptor. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without BPH. Also provided are processes for preparing such compounds, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof.