RENIN INHIBITORS

Disclosed are compounds according to Formula I: wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described herein are metho...

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Bibliographische Detailangaben
Hauptverfasser:	TERRELL LAMONT R, DILLARD LAWRENCE W, SIMPSON ROBERT D, SEMUS SIMON, KALLANDER LARA S, GHIRLANDA DAMIANO, ISHCHENKO ALEXEY V, CLAREMON DAVID A, LEACH COLIN A, ZHANG JING, MCGEEHAN GERARD, YUAN JING, CACATIAN SALVACION, XU ZHENRONG, SINGH SURESH B, LU QING, ZHAO WEI, HOU XIAOPING, TICE COLIN M, FLAHERTY PATRICK T, LAWHORN BRIAN, BALDWIN JOHN J, GHAVINI-ALAGHA BAHMAN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds according to Formula I: wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.