METHOD AND SYSTEM FOR SELECTING CHEMOTHERAPEUTIC AGENTS

Described herein is a method and corresponding system, including reagents and assays, for determining the in vivo efficacy of drugs in the course of chemotherapy. The method can include identifying a patient having a condition, such as leukemia, that is potentially susceptible to one or more candida...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BELTZ LISA A, BUMPUS JOHN A
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein is a method and corresponding system, including reagents and assays, for determining the in vivo efficacy of drugs in the course of chemotherapy. The method can include identifying a patient having a condition, such as leukemia, that is potentially susceptible to one or more candidate drugs having a particular in vivo biochemical activity, such as the generation of reactive oxygen or nitrogen species. An in vitro biochemical assay is provided that corresponds to the biochemical activity, and a tissue sample is tested to determine the responsiveness of the tissue sample to the biochemical activity, for instance, the ability of the tissue sample to degrade or inhibit the active species (in this case, hydrogen peroxide), and thereby prevent its desired effect against the cancerous cells. A course of chemotherapy can be based, at least in part, on the responsiveness of the tissue sample to the biochemical activity.