TRUNCATED MEMAPSIN 2 COMPOSITIONS AND TREATMENTS

The present invention provides novel methods of reducing memapsin 2 beta-secretase activity in a subject, decreasing levels of beta-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of beta-amyloid plaques in the brain of a subject. T...

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Bibliographische Detailangaben
Hauptverfasser:	DOWNS DEBORAH, CHANG WAN PIN, TANG JORDAN J.N
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides novel methods of reducing memapsin 2 beta-secretase activity in a subject, decreasing levels of beta-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of beta-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.