IMMUNOMAGNETIC CAPTURE AND IMAGING OF BIOLOGICAL TARGETS

The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sa...

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Bibliographische Detailangaben
Hauptverfasser: COLLINS CHARLES J, BERNARD BRUCE J-C, HOFFACKER KURT D
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sample mixture is done by immunomagnetic separation. Upon introduction of the sample within an imaging chamber, the capture complex (biological target-magnetic capture agent) will be attracted by the magnetic field and will lay on the surface of the chamber in the focal plane of the imaging system.