MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection...

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Hauptverfasser: JIANG YUTONG, JOSEY JOHN A, BLATT LAWRENCE M, ANDREWS STEVEN W, KENNEDY APRIL L, CONDROSKI KEVIN R, MADDURU MACHENDER R, WOODARD LAURA, DOHERTY GEORGE A, WOODARD BENJAMIN T, WENGLOWSKY STEVEN M, STENGEL PETER J
Format: Patent
Sprache:eng
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Zusammenfassung:The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.