Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors

Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors

The invention provides a compound of formula (I) or a salt thereof: wherein: R1 is C1-3alkyl, C1-3fluoroalkyl, or -CH2CH2OH; R2 is hydrogen, methyl or C1fluoroalkyl; R3 is of sub-formula (aa) or (bb): wherein Y is NCONH2 and n1 is 0 or 1; R4 is H; and R5 is a group of the sub-formula (x), (y), (y1)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JOHNSON MARTIN REDPATH, REDGRAVE ALISON JUDITH, COOK CAROLINE MARY, LINDVALL MIKA KRISTIAN, DOWLE MICHAEL DENNIS, JONES PAUL SPENCER, TRIVEDI NAIMISHA, EDLIN CHRISTOPHER DAVID
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides a compound of formula (I) or a salt thereof: wherein: R1 is C1-3alkyl, C1-3fluoroalkyl, or -CH2CH2OH; R2 is hydrogen, methyl or C1fluoroalkyl; R3 is of sub-formula (aa) or (bb): wherein Y is NCONH2 and n1 is 0 or 1; R4 is H; and R5 is a group of the sub-formula (x), (y), (y1) or (z): These compounds are PDE4 inhibitors.