Cell Sorting System and Methods

Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 100...

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Bibliographische Detailangaben
Hauptverfasser:	MARCHAND PHILIPPE, LAI BENJAMIN, BUTLER WILLIAM FRANK, FRANCIS JOHN, ZHANG YI, AHN KEUNHO, TU EUGENE, ZHANG HAICHUAN
Format:	Patent
Sprache:	eng
Schlagworte:	ACTUATING-FLOATS APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY BLASTING CHEMISTRY COCKS DEVICES FOR VENTING OR AERATING ENGINEERING ELEMENTS AND UNITS ENZYMOLOGY GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS HEATING LIGHTING MECHANICAL ENGINEERING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS TAPS THERMAL INSULATION IN GENERAL VALVES VINEGAR WEAPONS WINE
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Beschreibung
Zusammenfassung:	Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.