Acylated Piperidines as Glycine Transporter Inhibitors

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, i...

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Bibliographische Detailangaben
Hauptverfasser:	WARD SIMON EDWARD, EVANS BRIAN, CHAN WAI NGOR, BRADLEY DANIEL MARCUS, BRANCH CLIVE LESLIE, NASH DAVID JOHN, COULTON STEVEN, MARSHALL HOWARD ROBERT, PORTER RODERICK ALAN, DOYLE PAUL MARTIN, GILPIN MARTIN LEONARD, GOUGH SHARON LISA, DEAN ANTHONY WILLIAM, MACRITCHIE JACQUELINE ANNE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.