Reactors for selective enhancement reactions and methods of using such reactors

Micro-reactors for selective enhancement of ligands by exponential enrichment (ISOS) include a reactant chamber defined in a fluoropolymer. A target exposure aperture controls a surface area, crystal face or orientation and surface features of a target that is exposed to a random mixture of candidat...

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Hauptverfasser:	HUTCHISON JAMES E, SWEENEY SCOTT F, MAHADY AMY E, BERGLUND JOHN A
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMBINATORIAL CHEMISTRY ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Micro-reactors for selective enhancement of ligands by exponential enrichment (ISOS) include a reactant chamber defined in a fluoropolymer. A target exposure aperture controls a surface area, crystal face or orientation and surface features of a target that is exposed to a random mixture of candidate molecules. The surface area of the target can be selected based on number or concentration of candidate species to enhance candidate competition. The target surface can be formed by deposition of a thin film of a target material on a rigid substrate such as a glass plate. Selected exposure areas are typically substantially smaller than a characteristic cross sectional area of a reactant chamber volume and can be at least as small as 0.1 mm2.