Cardiovascular safety assay

The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAN ASSOUW HENRICUS PETRUS MARTINUS, MIREK JURZAK, JANSSEN CORNELUS GARARDUS MARIA, HEYLEN GODELIEVE IRMA CHRISTINE MARIA
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.