HETEROLOGOUS PRODUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1Ra) IN PICHIA PASTORIS

HETEROLOGOUS PRODUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (IL-1Ra) IN PICHIA PASTORIS

The invention relates to the production and expression of Interleukin 1 receptor antagonist (IL-1Ra) in expression systems, such as Pichia Pastoris (P. pastoris). For example, the present invention encompasses an engineered Pichia strain x-33/pGAPZalphaA/IL-1Ra constructed by cloning the IL-1Ra gene...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KONDIBOYINA VENKATA RAMANA, SHIVRAJ LIVY, PALANDE PRADNYA
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to the production and expression of Interleukin 1 receptor antagonist (IL-1Ra) in expression systems, such as Pichia Pastoris (P. pastoris). For example, the present invention encompasses an engineered Pichia strain x-33/pGAPZalphaA/IL-1Ra constructed by cloning the IL-1Ra gene in pGAPZalphaA and transforming the recombinant vector into Pichia Pastoris x-33.