Per-6-Guanidino-, Alkylamino-Cyclodextrins, Methods Of Their Synthesis And Their Use For The Compaction Of Dna And Interacellular Delivery

The invention relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n, -R1)alpha-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)-(beta-cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)-gamma-cyclodextrin, where n=2-6 when R1-NH2 and n=0 when R1-C(-NH)NH2 and n=2-6 when R1-NH-C(-NH)NH2 and their...

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Hauptverfasser:	YANNAKOPOULOU KONSTANTINA, AGELIDOU CHRYSI, MAVRIDIS IRENE M, MOURTZIS NIKOLAOS, ELIADOU KYRIAKI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The invention relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n, -R1)alpha-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)-(beta-cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)-gamma-cyclodextrin, where n=2-6 when R1-NH2 and n=0 when R1-C(-NH)NH2 and n=2-6 when R1-NH-C(-NH)NH2 and their use in the compaction of DNA and in cell permeation. The invention also relates to methods of synthesis of the above compounds.