Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing...

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Hauptverfasser: HAFNER STEFAN, ZELDER OSKAR, SCHRODER HARTWIG, KIEFER PATRICK, WITTMANN CHRISTOPH, KLOPPROGGE CORINNA, KROGER BURKHARD, HEINZLE ELMAR
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.