Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors
The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl,...
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| creator | COE DIANE M ALLEN DAVID G LINDVALL MIKA K COOK CAROLINE M HAMBLIN JULIE N REDGRAVE ALISON J JONES PAUL S EDLIN CHRISTOPHER D DOWLE MICHAEL D MITCHELL CHARLOTTE J TRIVEDI NAIMISHA JOHNSON MARTIN R |
| description | The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors. |
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Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors</title><source>esp@cenet</source><creator>COE DIANE M ; ALLEN DAVID G ; LINDVALL MIKA K ; COOK CAROLINE M ; HAMBLIN JULIE N ; REDGRAVE ALISON J ; JONES PAUL S ; EDLIN CHRISTOPHER D ; DOWLE MICHAEL D ; MITCHELL CHARLOTTE J ; TRIVEDI NAIMISHA ; JOHNSON MARTIN R</creator><creatorcontrib>COE DIANE M ; ALLEN DAVID G ; LINDVALL MIKA K ; COOK CAROLINE M ; HAMBLIN JULIE N ; REDGRAVE ALISON J ; JONES PAUL S ; EDLIN CHRISTOPHER D ; DOWLE MICHAEL D ; MITCHELL CHARLOTTE J ; TRIVEDI NAIMISHA ; JOHNSON MARTIN R</creatorcontrib><description>The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080124&DB=EPODOC&CC=US&NR=2008021058A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080124&DB=EPODOC&CC=US&NR=2008021058A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COE DIANE M</creatorcontrib><creatorcontrib>ALLEN DAVID G</creatorcontrib><creatorcontrib>LINDVALL MIKA K</creatorcontrib><creatorcontrib>COOK CAROLINE M</creatorcontrib><creatorcontrib>HAMBLIN JULIE N</creatorcontrib><creatorcontrib>REDGRAVE ALISON J</creatorcontrib><creatorcontrib>JONES PAUL S</creatorcontrib><creatorcontrib>EDLIN CHRISTOPHER D</creatorcontrib><creatorcontrib>DOWLE MICHAEL D</creatorcontrib><creatorcontrib>MITCHELL CHARLOTTE J</creatorcontrib><creatorcontrib>TRIVEDI NAIMISHA</creatorcontrib><creatorcontrib>JOHNSON MARTIN R</creatorcontrib><title>Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors</title><description>The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4mDChbSNkLXWhTdCrarJZqTBGou5OpQn94OPoDTDx__NLpVQ1Af6gjW2U7GhyWMYLV1CCW9PL2dZiichtqgDdAwQsFQGWJvSFvkHoMasR48gtxUGuUWLs7Yu-0p8DyaPFXHuPh1Fq1Ox7o8x-ipRfbqgQ77trmmQuQiTcQ-L5Lsv-sLl5M6vA</recordid><startdate>20080124</startdate><enddate>20080124</enddate><creator>COE DIANE M</creator><creator>ALLEN DAVID G</creator><creator>LINDVALL MIKA K</creator><creator>COOK CAROLINE M</creator><creator>HAMBLIN JULIE N</creator><creator>REDGRAVE ALISON J</creator><creator>JONES PAUL S</creator><creator>EDLIN CHRISTOPHER D</creator><creator>DOWLE MICHAEL D</creator><creator>MITCHELL CHARLOTTE J</creator><creator>TRIVEDI NAIMISHA</creator><creator>JOHNSON MARTIN R</creator><scope>EVB</scope></search><sort><creationdate>20080124</creationdate><title>Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors</title><author>COE DIANE M ; ALLEN DAVID G ; LINDVALL MIKA K ; COOK CAROLINE M ; HAMBLIN JULIE N ; REDGRAVE ALISON J ; JONES PAUL S ; EDLIN CHRISTOPHER D ; DOWLE MICHAEL D ; MITCHELL CHARLOTTE J ; TRIVEDI NAIMISHA ; JOHNSON MARTIN R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2008021058A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>COE DIANE M</creatorcontrib><creatorcontrib>ALLEN DAVID G</creatorcontrib><creatorcontrib>LINDVALL MIKA K</creatorcontrib><creatorcontrib>COOK CAROLINE M</creatorcontrib><creatorcontrib>HAMBLIN JULIE N</creatorcontrib><creatorcontrib>REDGRAVE ALISON J</creatorcontrib><creatorcontrib>JONES PAUL S</creatorcontrib><creatorcontrib>EDLIN CHRISTOPHER D</creatorcontrib><creatorcontrib>DOWLE MICHAEL D</creatorcontrib><creatorcontrib>MITCHELL CHARLOTTE J</creatorcontrib><creatorcontrib>TRIVEDI NAIMISHA</creatorcontrib><creatorcontrib>JOHNSON MARTIN R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>COE DIANE M</au><au>ALLEN DAVID G</au><au>LINDVALL MIKA K</au><au>COOK CAROLINE M</au><au>HAMBLIN JULIE N</au><au>REDGRAVE ALISON J</au><au>JONES PAUL S</au><au>EDLIN CHRISTOPHER D</au><au>DOWLE MICHAEL D</au><au>MITCHELL CHARLOTTE J</au><au>TRIVEDI NAIMISHA</au><au>JOHNSON MARTIN R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors</title><date>2008-01-24</date><risdate>2008</risdate><abstract>The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors |
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