Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors

Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors

The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl,...

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Hauptverfasser: COE DIANE M, ALLEN DAVID G, LINDVALL MIKA K, COOK CAROLINE M, HAMBLIN JULIE N, REDGRAVE ALISON J, JONES PAUL S, EDLIN CHRISTOPHER D, DOWLE MICHAEL D, MITCHELL CHARLOTTE J, TRIVEDI NAIMISHA, JOHNSON MARTIN R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, -CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or -CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or -(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.