HIGH THROUGHPUT METHOD FOR SCREENING CANDIDATE COMPOUNDS FOR BIOLOGICAL ACTIVITY

A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate wit...

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Bibliographische Detailangaben
Hauptverfasser:	HAIZLIP JILL E, JAYAWICKREME CHANNA K, LIACOS JAMES A, MILLS KIRSTEN M, SHAFFER JOEL E, RUAN JASON J, KING HOLLY K, IGNAR DIANE M, SAULS HOWARD R.JR
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate with a plurality of candidate compound samples in a manner wherein an identity of each candidate compound can be determined and wherein the candidate compounds in the candidate compound samples interact with the target in the substrate; detecting a signal, the signal produced by the indicator upon interaction between the target and a candidate compound; and identifying a candidate compound as a modulator of the biological activity of the target based upon an amount of signal produced.