Diastereoselective Addition of Lithiated N-Methylimidazole on Sulfinimines

Diastereoselective Addition of Lithiated N-Methylimidazole on Sulfinimines

A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the preparation of a compound of formula (VIII) and the stereochemically isomeric forms thereof wherein R is...

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Bibliographische Detailangaben
Hauptverfasser: ANGIBAUD PATRICK R, FILLIERS WALTER F.M, BROECKX RUDY L.M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the preparation of a compound of formula (VIII) and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl-.