Water soluble micelle-forming and biodegradable cyclotriphosphazene-taxol conjugate anticancer agent and preparation method thereof

Water soluble micelle-forming and biodegradable cyclotriphosphazene-taxol conjugate anticancer agent and preparation method thereof

A water-soluble micelle-forming cyclotriphosphazene-taxol conjugate anticancer agent, which is biodegradable, and thus, slowly release taxol, represented by the following Formula 1: wherein R is selected from the group consisting of H, CH3, (CH3)2CH and (CH3)2CHCH2; each n is the number of ethylene...

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Bibliographische Detailangaben
Hauptverfasser: JI DA-EUN, JUN YONG-JOO, SOHN YOUN-SOO, LEE HWA-JEONG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Zusammenfassung:A water-soluble micelle-forming cyclotriphosphazene-taxol conjugate anticancer agent, which is biodegradable, and thus, slowly release taxol, represented by the following Formula 1: wherein R is selected from the group consisting of H, CH3, (CH3)2CH and (CH3)2CHCH2; each n is the number of ethylene oxide repeating unit of poly(ethylene glycol) selected from the integers of 7-12; and x is 1 or 2.