4-Substituted-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones

The present invention concerns combinations comprising a compound of formula (I) the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters or metabolites thereof, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4al...

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Hauptverfasser: KESTELEYN BART R.R, WANG JING, CANARD MAXIME FRANCIS J.G, VAN DE VREKEN WIM, DE VROEY VERONIQUE C.P, SURLERAUX DOMINIQUE LOUIS N.G, WIGERINCK PIET T.B, KINDERMANS NATALIE M.F, JOCHMANS DIRK E.D, HERTOGS KURT, BETTENS EVA, TAHRI ABDELLAH
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention concerns combinations comprising a compound of formula (I) the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters or metabolites thereof, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(-O), N-(aryl)-N-(C1-4alkyl)aminoC(-O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-4alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(-O), aminoC(-O), C1-4alkyloxyC(-O), mono- or di(C1-4alkyl)aminoC(-O), C1-4alkylC(-O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; and another HIV inhibitor. The invention also concerns products comprising a compound of formula (I) and another HIV inhibitor, as a combined preparation for simultaneous, separate or sequential use in treatment of retroviral infections such as HIV infection, in particular, in the treatment of infections with multi-drug resistant retroviruses.