Diastereoselective Synthesis Process for the Preparation of Imidazole Compounds

Diastereoselective Synthesis Process for the Preparation of Imidazole Compounds

A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4 -chlomphenyl)(I-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl...

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Bibliographische Detailangaben
Hauptverfasser: ANGIBAUD PATRICK R, FILLIERS WALTER F.M, BROECKX RUDY LAURENT M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4 -chlomphenyl)(I-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl2(IH)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with C1-6alkyloxy.