PRODUCTION OF MULTIVESICULAR LIPOSOMES

Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process...

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Bibliographische Detailangaben
Hauptverfasser:	MEISSNER DAGMAR, PEPPER CLINT B, HARTOUNIAN HARTOUN
Format:	Patent
Sprache:	eng
Schlagworte:	BABY COMFORTERS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES CONVEYING DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HANDLING THIN OR FILAMENTARY MATERIAL HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PACKING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PNEUMATIC TUBE CONVEYORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SHOP CONVEYOR SYSTEMS STORING THEIR RELEVANT APPARATUS TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING ORTIPPING TRANSPORTING
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Beschreibung
Zusammenfassung:	Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.