Indene Derivatives and Process for the Preparation Thereof

Indene Derivatives and Process for the Preparation Thereof

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic sy...

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Hauptverfasser: AHN JIN HEE, CHEON HYAE GYEONG, YANG SUNG-DON, YOO SUNG-EUN, MO KIL WOONG, KANG SEUNG KYU, KIM SUN MEE, KIM SUNG SOO, LEE JEONG-HYUNG, KIM KWANG-ROK, LEE JAE MOK, RHEE SANG DAL, KIM SEUNG JUN, PARK SUNG DAE, LEE KOUN HO, KIM NAM GEE, JUNG WON HOON, KANG HYE JUNG, KIM JONG HOON
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.