System for the Evaluation of Tracer Concentration in a Reference Tissue and a Target Region

System for the Evaluation of Tracer Concentration in a Reference Tissue and a Target Region

The invention relates to the estimation of kinetic parameters for a target region ( 210 ) utilizing information from a normal (unperturbed) reference region ( 200 ). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure fea...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SPIES LOTHAR, PAULUS TIMO, PELIGRAD DRAGOS-NICOLAE
Format: Patent
Sprache:eng
Schlagworte:
DIAGNOSIS
HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
SURGERY
TESTING
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Beschreibung
Zusammenfassung:The invention relates to the estimation of kinetic parameters for a target region ( 210 ) utilizing information from a normal (unperturbed) reference region ( 200 ). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region ( 200 ) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region ( 210 ). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent SB(t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.