Certain chemical entities, compositions and methods

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

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Bibliographische Detailangaben
Hauptverfasser: TOCHIMOTO TODD, KRAYNACK ERICA A, MORGAN BRADLEY P, MUCI ALEX, LU PU-PING, MORGANS DAVID J.JR
Format: Patent
Sprache:eng
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Zusammenfassung:Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.